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Year : 2016  |  Volume : 6  |  Issue : 1  |  Page : 11-17

Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 in human periodontal intraosseous defects: A randomized controlled trial

1 Department of Periodontics, College of Dental Sciences, Davangere, Karnataka, India
2 Department of Periodontics, Himachal Dental College, Sundernagar, Himachal Pradesh, India

Correspondence Address:
Kharidi Laxman Vandana
Department of Periodontics, College of Dental Sciences, Davangere, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2231-6027.186658

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Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) technologies have been shown to significantly support alveolar bone. The purpose of this study was to explore the effect of rhBMP-2 following periodontal flap surgery in vertical defects on clinical and radiological parameters. Methods: A randomized double-blind controlled trial was carried out, wherein rhBMP-2 was used in the test group after open flap debridement (OFD). The control group was only OFD. The same examiner carried out both clinical and radiographic measurements at baseline, 6 and 9 months. Results: In rhBMP-2 + OFD sites, the probing pocket depth reduction was 1.45 ± 0.76, 2.50 ± 0.69 at 6 months and 9 months, respectively (both P < 0.001) and clinical attachment gain was 0.92 ± 0.76, 1.31 ± 0.48 at 6 months, and 9 months, respectively (both P < 0.001). Radiographic fill was 1.14 ± 0.73, 1.85 ± 0.83 at 6 months, and 9 months postoperatively (P < 0.001) and percentage of original defect resolved at 6 and 9 months was 40.2 ± 18.6, 60.1 ± 15.8, respectively. Conclusions: The periodontal therapy can include rhBMP-2 to enhance periodontal regeneration. The clinical and radiographic improvement are demonstrated in this study.

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