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Year : 2020  |  Volume : 10  |  Issue : 2  |  Page : 94-101

A randomized clinical trial of antimicrobial efficacy of photoactivated disinfection, conventional endodontic irrigation and their combination in primary endodontic infections

Department of Conservative Dentistry and Endodontics, Sudha Rustagi College of Dental Sciences and Research, Faridabad, Haryana, India

Correspondence Address:
Dr. Varsha Jain
Department of Conservative Dentistry and Endodontics, Sudha Rustagi College of Dental Sciences and Research, Sector 89, Kheri More, Faridabad - 121 002, Haryana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijohs.ijohs_20_20

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Aim: The aim of this study is to evaluate and compare the antimicrobial efficacy of photoactivated disinfection (PAD), conventional irrigation (CEI), and combination of both against primary endodontic infections in vivo. Methods: Active controlled and parallel design trial was registered with Clinical Trials Registry India under reference no. CTRI/2018/08/015478. Forty-eight qualified patients were randomly divided into three groups (n = 16 each) using the lottery method, Group-I: CEI, Group-II: PAD, Group-III: CEI and PAD. Access opening and working length were determined, and preinstrumentation sample (S1) was taken by inserting sterile paper point into the canal. Postinstrumentation sample (S2) was collected following biomechanical preparation and irrigation with respective interventions. Microbiological samples (S1, S2) were plated on brain heart infusion agar. Colony-forming units were counted using the classic bacterial counting method, and percentage bacterial reduction was determined. Statistical Analysis: Inter- and intra-group comparison was made using repeated measures of ANOVA. Post hoc Tukey analysis was done for pairwise comparison with P < 0.05. Results: In the intragroup comparison, statistically significant reduction was seen at S2 among all experimental groups. However, in intergroup comparison, mean bacterial reduction in Group III was significantly lower than the other groups. This difference was statistically significantly better between Group I and Group III; Group II, and Group III. However, no statistically significant difference was seen between Group I and Group II. Within the limitations of this study, it can be concluded that a combination of CEI and PAD showed significantly better antimicrobial activity against primary endodontic infections and can be recommended as an adjunct to facilitate maximum root canal disinfection.

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